Table 2: Predicted neuropeptide-like precursors and their mature neuropeptides in C. elegans. Peptide sequence are shown without any posttranslational modifications. Sequences indicated in bold have been biochemically isolated in previous studies. Possible modifications include: N-terminal cyclization of a glutamic acid or glutamine residue and pyroglutamate formation, C-terminal conversion of a glycine residue into an amide, formation of disulfide bridge between two cysteine residues.


[1] McVeigh P., Leech S., Mair G.R., Marks N.J., Geary T.G., Maule A.G. (2005). Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda. Int. J. Parasitol., 35(10): p. 1043-60.
[2] McCoy C.J., Atkinson L.E., Zamanian M., McVeigh P., Day T.A., Kimber M.J., Marks N.J., Maule A.G., Mousley A. (2014). New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches. EuPA Open Proteom, 3: p. 262-272.
[3] Hobert O. (2013). The neuronal genome of Caenorhabditis elegans. WormBook: p. 1-106.
[4] Li C. & Kim K. (2010). Neuropeptide Gene Families in Caenorhabditis elegans. Advances in experimental medicine and biology. Vol. 692. 98-137.
[5] Peymen K., Watteyne J., Frooninckx L., Schoofs L., Beets I. (2014). The FMRFamide-Like Peptide Family in Nematodes. Front Endocrinol (Lausanne), 5: p. 90.
[6] Li C. & Kim K. (2014). Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes. Front Endocrinol (Lausanne), 5: p. 150.
[7] Van Bael S., Zels S., Boonen K., Beets I., Schoofs L., Temmerman L. (2018). A Caenorhabditis elegans Mass Spectrometric Resource for Neuropeptidomics. J. Am. Soc. Mass Spectrom. 29(5): p. 879-889.
[8] Li C. & Kim K. (2008). Neuropeptides. WormBook: p. 1-36.
[9] Husson S.J., Reumer A., Temmerman L., De Haes W., Schoofs L., Mertens I., Baggerman G. (2014). Worm peptidomics. EuPA Open Proteom, 3: p. 280-290.
[10] Husson S.J., Lindemans M., Janssen T., Schoofs L. (2009). Comparison of Caenorhabditis elegans NLP peptides with arthropod neuropeptides. Trends Parasitol., 25(4): p. 171-81.
[11] Husson S.J., Mertens I., Janssen T., Lindemans M., Schoofs L. (2007). Neuropeptidergic signaling in the nematode Caenorhabditis elegans. Prog. Neurobiol., 82(1): p. 33-55.
[12] Li C. (2005). The ever-expanding neuropeptide gene families in the nematode Caenorhabditis elegans. Parasitology, 131 Suppl: p. S109-27.
[13] McVeigh P., Alexander-Bowman S., Veal E., Mousley A., Marks N.J., Maule A.G. (2008). Neuropeptide-like protein diversity in phylum Nematoda. Int. J. Parasitol., 38(13): p. 1493-503.
[14] Lindemans M., Liu F., Janssen T., Husson S.J., Mertens I., Gade G., Schoofs L. (2009). Adipokinetic hormone signaling through the gonadotropin-releasing hormone receptor modulates egg-laying in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A., 106(5): p. 1642-7.
[15] Van Sinay E., Mirabeau O., Depuydt G., Van Hiel M.B., Peymen K., Watteyne J., Zels S., Schoofs L., Beets I. (2017). Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A., 114(20): p. E4065-E4074.
[16] Koziol U., Koziol M., Preza M., Costabile A., Brehm K., Castillo E. (2016). De novo discovery of neuropeptides in the genomes of parasitic flatworms using a novel comparative approach. Int. J. Parasitol., 46(11): p. 709-21.
[17] Mirabeau O. & Joly J.S. (2013). Molecular evolution of peptidergic signaling systems in bilaterians. Proc. Natl. Acad. Sci. U.S.A., 110(22): p. E2028-37.
[18] Janssen T., Husson S.J., Meelkop E., Temmerman L., Lindemans M., Verstraelen K., Rademakers S., Mertens I., Nitabach M., Jansen G., Schoofs L. (2009). Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans. J. Neurochem., 111(1): p. 228-41.
[19] Beets I., Janssen T., Meelkop E., Temmerman L., Suetens N., Rademakers S., Jansen G., Schoofs L. (2012). Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans. Science, 338(6106): p. 543-5.
[20] Yamada K., Hirotsu T., Matsuki M., Butcher R.A., Tomioka M., Ishihara T., Clardy J., Kunitomo H., Iino Y. (2010) Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science, 329(5999): p. 1647-50.